Methods and uses of TIE2 binding and/or activating agents

摘要

The present disclosure provides methods and uses of Tie2 binding and/or activating agents. In particular, the present disclosure provides methods and uses for inhibiting the expansion of colony forming unit-granulocytes, reducing eosinophils and/or basophils, for treating allergic disease or response or eosinophil/basophil associated condition and for reducing inflammatory cytokine and/or chemokine levels.

主权项

1. A method for reducing eosinophils and/or basophils in an animal in need thereof comprising administering a multimeric form of Tie2 binding peptide monomers to the animal in need thereof, wherein the multimeric form has Tie2 agonist activity, wherein each peptide monomer comprises:
(i) a T7 peptide (SEQ ID NO:1) or a T7 modified peptide (SEQ ID NO:2); (ii) a GA3 peptide (SEQ ID NO:3) or a GA3 modified peptide (SEQ ID NO:4); (iii) a T4 peptide (SEQ ID NO:9) or a T4 modified peptide (SEQ ID NO:10); (iv) a T6 peptide (SEQ ID NO:7) or a T6 modified peptide (SEQ ID NO:8); or (v) a T8 peptide (SEQ ID NO:5) or a T8 modified peptide (SEQ ID NO:6); and wherein the Tie2 binding peptide monomers are multimerized via a linking moiety, spacer and/or multimerizing agent.