The present invention provides a combination therapy which relies on a small molecule immune stimulator—cyclic-di-nucleotide (CDN)—that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.
申请公布号
HK1204302(A1)
申请公布日期
2015.11.13
申请号
HK20150104847
申请日期
2015.05.21
申请人
ADURO BIOTECH;THE JOHN HOPKINS UNIVERSITY
发明人
DUBENSKY, THOMAS, W. T W;LEONG, MEREDITH, LIA LING M L L;PARDOLL, DREW, M. D M;KIM, YOUNG, JUN Y J