| 发明名称 |
RECOMBINANT HUMAN IgM-ANTIBODY EFFECTIVE AGAINST CANCER CELLS |
| 摘要 |
A recombinant human monoclonal pentameric IgM antibody comprising the capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and GM1 and the capability of specific binding to malignant cancer cells selected from the group consisting of melanoma cells, small cell lung cancer cells, glioblastoma cells, and estrogen receptor-negative metastatic breast cancer cells; a cell line producing the IgM antibody; and the use of the IgM antibody as a diagnostic tool and/or as a therapeutic agent. |
| 申请公布号 |
US2015322161(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201314646166 |
申请日期 |
2013.11.26 |
| 申请人 |
KATINGER GMBH |
发明人 |
KATINGER Hermann;KUNERT Renate;STEROVSKY Thomas;HEMETSBERGER Thomas |
| 分类号 |
C07K16/30;G01N33/577 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant human or humanized monoclonal pentameric IgM antibody comprising the following characteristics:
capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and GM1 and capability of specific binding to malignant cancer cells selected from the group consisting of melanoma cells, small cell lung cancer cells, glioblastoma cells, estrogen receptor-negative metastatic breast cancer cells. |
| 地址 |
Vienna AT |
