| 发明名称 |
ENGINEERED MONOMERIC ANTIBODY FRAGMENTS |
| 摘要 |
The present invention relates to monomeric polypeptides comprising an engineered monomeric antibody fragment (e.g., monomeric Fc-containing polypeptides) wherein the monomeric Fc comprises one or more engineered N-linked glycosylation sites in the CH3-CH3 dimerization interface. Methods for producing such engineered monomeric antibody fragments and their use in diagnostics and therapeutics are also provided. |
| 申请公布号 |
US2015322135(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201314650188 |
申请日期 |
2013.11.25 |
| 申请人 |
PFIZER INC. |
发明人 |
Ishino Tetsuya;Duan Weili;Kriz Ronald William |
| 分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A monomeric Fc-containing polypeptide comprising an IgG CH2 and an IgG CH3 domain, wherein the CH3 domain comprises one or more engineered N-linked glycosylation sites in the CH3-CH3 dimerization interface, wherein the engineered N-linked glycosylation site comprises at least two amino acid modifications having a consensus sequence of Asn-X-Ser or Asn-X-Thr, wherein X is any amino acid except Pro. |
| 地址 |
New York NY US |
