PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

摘要

The invention relates to novel heterocyclic compounds of the formula;;in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

主权项

1. A compound, or a pharmaceutically acceptable salt thereof, which is selected from the group consisting of:
5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Chloro-pyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-4-ethyl-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 3,5-Dichloro-pyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 3,5-Dichloro-pyridine-2-carboxylic acid [3-(6-amino-4-ethyl-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-4-isopropyl-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 3,5-Dichloro-pyridine-2-carboxylic acid {3-[6-amino-4-(2-methoxy-ethyl)-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl]-4-fluoro-phenyl}-amide; 5-Bromo-pyridine-2-carboxylic acid {3-[6-amino-4-(2-methoxy-ethyl)-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl]-4-fluoro-phenyl}-amide; 5-Bromo-pyridine-2-carboxylic acid {3-[6-amino-2-methyl-4-(1-methyl-1H-pyrazol-4-yl)-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl]-4-fluoro-phenyl}-amide; 5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-2-methyl-5-oxo-4-pyridin-3-yl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Cyano-pyridine-2-carboxylic acid [3-(6-amino-4-ethyl-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Bromo-pyridine-2-carboxylic acid [3-(6-amino-5-ethyl-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-phenyl]-amide; 5-Cyano-pyridine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Cyano-pyridine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Amino-3-{5-[(5-bromo-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid methyl ester; 5-Amino-3-{5-[(5-cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid methyl ester; 5-Bromo-3-methyl-pyridine-2-carboxylic acid [3-(4-acetyl-6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Amino-3-{5-[(5-bromo-3-methyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2-dichloro-ethyl ester; 5-Bromo-3-methyl-pyridine-2-carboxylic acid {3-[6-amino-2-difluoromethyl-4-(2-methoxy-acetyl)-2,3,4,5-tetrahydro-pyrazin-2-yl]-4-fluoro-phenyl}-amide; 5-Bromo-3-methyl-pyridine-2-carboxylic acid [3-(6-amino-4-cyclopropanecarbonyl-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Bromo-3-methyl-pyridine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Difluoromethoxy-3-methyl-pyridine-2-carboxylic acid [3-(4-acetyl-6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 5-Difluoromethoxy-3-methyl-pyridine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; 3-Amino-5-methoxy-pyrazine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide; and 3-Amino-5-oxo-4,5-dihydro-pyrazine-2-carboxylic acid [3-(6-amino-2-difluoromethyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-4-fluoro-phenyl]-amide.