SYSTEMS AND METHODS TO IMPROVE ORGAN OR TISSUE FUNCTION AND ORGAN OR TISSUE TRANSPLANT LONGEVITY

摘要

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

主权项

1. A method for improving organ or tissue function or organ or tissue transplant longevity, comprising: administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy, at a constant alveolar concentration for at least about 30 minutes.