| 发明名称 |
RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF |
| 摘要 |
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. |
| 申请公布号 |
US2015322420(A9) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201012823098 |
申请日期 |
2010.06.24 |
| 申请人 |
FRANANO F. NICHOLAS;BLAND KIMBERLY S.;WONG MARCO D.;DING BEE C. |
发明人 |
FRANANO F. NICHOLAS;BLAND KIMBERLY S.;WONG MARCO D.;DING BEE C. |
| 分类号 |
C12N9/66;C12P21/00;C12N15/63;C12N1/15;C07K14/00;C07H21/00 |
主分类号 |
C12N9/66 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A proelastase protein comprising (i) optionally, a signal sequence; (ii) an elastase activation peptide sequence comprising an elastase recognition sequence operably linked to (iii) an amino acid sequence of a type I mature elastase. |
| 地址 |
KANSAS CITY MO US |
