| 发明名称 |
SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION |
| 摘要 |
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided. |
| 申请公布号 |
US2015322429(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201414558402 |
申请日期 |
2014.12.02 |
| 申请人 |
GENZYME CORPORATION |
发明人 |
Crooke Rosanne M.;Graham Mark J.;Mah Steven |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antisense compound 15 to 30 nucleobases in length which specifically hybridizes with an allelic variant of a nucleic acid of SEQ ID NO: 1 encoding human apolipoprotein B, wherein said compound inhibits the expression of apolipoprotein B mRNA by at least 10% and wherein said compound is targeted to a region that includes a cytosine (C) at position 27735 of SEQ ID NO: 1. |
| 地址 |
CAMBRIDGE MA US |
