| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
R1 is represented by a substituent selected from the group consisting of (C3-C10)cycloalkyl, a (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and a (5- to 10-membered) heteroaryl; wherein said (C3-C10)cycloalkyl, (C6-C10)aryl and (5- to 10-membered)heteroaryl are optionally substituted with (R2)b; and said (4- to 10-membered)heterocycloalkyl is optionally substituted at one to five carbon atoms with a substituent independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio, —C(O)NR4R5, hydroxy, and cyano, and optionally substituted at each available nitrogen with (C1-C6)alkyl; R2 is represented by a substituent independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio; —C(O)NR4R5, hydroxy, and cyano; R3, if present, at each occurrence is represented by a substituent independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio, —C(O)NR4R5, hydroxy, and cyano; R4 and R5 are each represented by a substituent independently selected from the group consisting of hydrogen, (C1-C6)alkyl, and (C3-C6)cycloalkyl; R6 and R7 are each represented by a substituent independently selected from the group consisting of hydrogen, (C1-C6)alkyl, —(CH2)m—(C3-C10)cycloalkyl, —(CH2)m-(4- to 10-membered)-heterocycloalkyl, —(CH2)m—(C6-C10)aryl, and —(CH2)m-(5- to 10-membered)heteroaryl; wherein said (C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, and (5- to 10-membered)heteroaryl are optionally substituted with one to five substituents independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio, —C(O)NR4R5, hydroxy, and cyano; and said (4- to 10-membered)heterocycloalkyl is optionally substituted at one to five carbon atoms with a substituent independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio, —C(O)NR4R5, hydroxy, and cyano, and optionally substituted at each available nitrogen with (C1-C6)alkyl; or R6 and R7 taken together with the nitrogen to which they are attached form a (4- to 10-membered)heterocycloalkyl, wherein said (4- to 10-membered) heterocycloalkyl is optionally substituted at one to five carbon atoms with a substituent independently selected from the group consisting of halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylthio, —C(O)NR4R5, hydroxy, and cyano; a is represented by an integer selected from 0, 1, 2 or 3; b is represented by an integer selected from 0, 1, 2, 3, 4 or 5; and m is represented by an integer selected from 0, 1, 2, or 3. |
