发明名称 |
TAMPER RESISTANT IMMEDIATE RELEASE CAPSULE FORMULATION COMPRISING TAPENTADOL |
摘要 |
The invention is directed to an immediate release capsule which mitigates the abuse of Tapentadol or physiologically acceptable salt thereof by direct intravenous injection. The capsule comprises a tamper resistant formulation which when mixed with water and heated, results in a turbid, bubbling mixture that is not injectable with a standard insulin syringe. |
申请公布号 |
US2015320690(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
US201514709124 |
申请日期 |
2015.05.11 |
申请人 |
GRÜNENTHAL GMBH |
发明人 |
FRIEDRICH Ingo;FUHRHERR Richard;MÖSCHTER Silke;WENGNER Simone |
分类号 |
A61K9/48;A61K31/137 |
主分类号 |
A61K9/48 |
代理机构 |
|
代理人 |
|
主权项 |
1. A tamper resistant pharmaceutical capsule comprising a capsule filling and a capsule shell, wherein said capsule filling is encapsulated by said capsule shell and comprises:
(a) Tapentadol or a physiologically acceptable salt thereof in an amount within the range of from 10 mg to 400 mg, as equivalent weight relative to Tapentadol free base; and (b) a liquid excipient blend comprising a solvent, a surfactant, and a viscosity enhancer; wherein the capsule provides immediate release of Tapentadol or the physiologically acceptable salt thereof upon oral administration. |
地址 |
Aachen DE |