| 发明名称 |
FIBROTIC NON-HUMAN ANIMAL, AND USE THEREOF |
| 摘要 |
The present invention provides a non-human animal IKKβ which shows fibrosis of tissue, since it lacks IKKβ gene in a myofibroblast- and/or smooth muscle cell-specific manner. Since the non-human animal shows pathology highly similar to scleroderma, it is extremely useful as an animal model of scleroderma. |
| 申请公布号 |
US2015320020(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201314439885 |
申请日期 |
2013.10.31 |
| 申请人 |
KYOTO UNIVERSITY ;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ASHIDA Noboru;YOKODE Masayuki;KARIN Michael;NGUYEN TIEN Dat |
| 分类号 |
A01K67/027;G01N33/50;A61K49/00 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A non-human animal showing fibrosis of tissue, which lacks IKKβ gene in a myofibroblast- and/or smooth muscle cell-specific manner, or a part of the living body thereof. |
| 地址 |
Kyoto JP |
