发明名称 |
SUBSTITUTED PYRIMIDINE AMINOALKYL-QUINAZOLONES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS |
摘要 |
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which R1, R2, n, R3, R4, R5 and R6 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ. |
申请公布号 |
EP2941426(A1) |
申请公布日期 |
2015.11.11 |
申请号 |
EP20130821357 |
申请日期 |
2013.12.20 |
申请人 |
GILEAD CALISTOGA LLC |
发明人 |
EVARTS, JERRY;PATEL, LEENA;TREIBERG, JENNIFER, A.;PERREAULT, STEPHANE;YEUNG, ARTHUR;PURVIS, LAFE, J., II;KIM, MUSONG |
分类号 |
C07D403/12;A61K31/517;A61P29/00;A61P35/00;C07D401/14;C07D403/14;C07D471/08 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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