发明名称 |
Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
摘要 |
The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester
or
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester benzene sulfonate (P)
which comprises reacting 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester of formula (EM)
with an oxidizing agent and optionally treating the reaction product under acidic conditions, such as to produce the compound of formula (F) or the compound (P), and new compounds useful as starting material or as intermediate for performing that process. |
申请公布号 |
EP2477967(B1) |
申请公布日期 |
2015.11.11 |
申请号 |
EP20100760917 |
申请日期 |
2010.09.15 |
申请人 |
PAION UK LIMITED |
发明人 |
TILBROOK, STUART, GARY;SCHUMACHER, ANDREAS;EMMENEGGER, RENÉ |
分类号 |
C07D213/16;C07D213/18;C07D401/04;C07D487/04 |
主分类号 |
C07D213/16 |
代理机构 |
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代理人 |
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