| 发明名称 | Truncated ACTRIIB-FC fusion protein | ||
| 摘要 | In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue. | ||
| 申请公布号 | US9181533(B2) | 申请公布日期 | 2015.11.10 |
| 申请号 | US201213657649 | 申请日期 | 2012.10.22 |
| 申请人 | Acceleron Pharma, Inc. | 发明人 | Seehra Jasbir;Kumar Ravindra |
| 分类号 | C07K14/475;C12N9/12;C07K14/71;A61K38/00 | 主分类号 | C07K14/475 |
| 代理机构 | Ropes & Gray LLP | 代理人 | Ropes & Gray LLP |
| 主权项 | 1. A polypeptide selected from the group consisting of: a. a polypeptide wherein the amino acid sequence of the polypeptide consists of the sequence of SEQ ID NO: 8; b. a polypeptide produced by the expression in a mammalian cell of the nucleic acid of SEQ ID NO: 4; and c. a polypeptide produced by the expression in a mammalian cell of the nucleic acid of SEQ ID NO: 6. | ||
| 地址 | Cambridge MA US | ||