Pharmaceutical preparation and manufacturing method thereof

摘要

This invention provides a pharmaceutical preparation for DDS containing a pharmaceutical agent fixed by bonding to a monomolecular layer that is covalently bonded to a magnetic particle surface, (a) by reacting an alkoxysilane compound with the magnetic microparticle surface by dispersing a magnetic microparticle in a liquid mixture including an epoxy-containing alkoxysilane compound, a silanol condensation catalyst, and a non-aqueous organic solvent; (b) by washing the microparticle surface with an organic solvent to remove remaining surplus alkoxysilane compound for producing an epoxy-containing monomolecular layer that is covalently bonded to the microparticle surface; and (c) by fixing an imino-containing pharmaceutical agent such as a protein, amino acid, enzyme, antibody, antibiotic, antimicrobial, or contrast medium by reaction with the epoxy group.

主权项

1. A particle comprising:
a magnetically sensitive particle; a first linker linked to the magnetically sensitive particle at one end and having an epoxy reaction product on the opposite end, the first linker being selected from the group consisting of (CH2OCH)CH2O(CH2)2Si(O)3, (CH2OCH)CH2O(CH2)11Si(O)3, (CH2CHOCH(CH2)2)CH(CH2)2Si(O)3, (CH2CHOCH(CH2)2)CH(CH2)4Si(O)3, (CH2CHOCH(CH2)2)CH(CH2)6Si(O)3, wherein the epoxy reaction product has a structure ofand
an agent having a terminal imino group linked to the epoxy reaction product opposite of the magnetically sensitive particle.