Coating layers for medical devices and method of making the same

摘要

Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.

主权项

1. A method comprising:
preparing a coating composition comprising one or more polymers, one or more active agents, and one or more solvents; applying the coating composition onto a surface of a medical device to form a wet coating layer; rapidly cooling the wet coating layer to a temperature of −150° C. or lower by exposing the wet coating layer to a cold gas or a cold liquid;
wherein the morphology of the one or more active agents is fixed; and after cooling the wet coating layer, removing solvent(s) to form a coating layer.