| 发明名称 | Mycobacterial vaccines | ||
| 摘要 | There is provided a fusion protein or a polynucleotide sequence encoding said fusion protein that comprises first and second domains, wherein the first domain of the fusion protein comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO: 1, or a fragment thereof comprising at least 20 consecutive amino acids thereof; and wherein the second domain of the fusion protein comprises a mycobacterial antigen or an antigenic fragment thereof. Also provided are corresponding therapeutic uses thereof for the protection of primates against mycobacterial infections. | ||
| 申请公布号 | US9181311(B2) | 申请公布日期 | 2015.11.10 |
| 申请号 | US201013501756 | 申请日期 | 2010.10.15 |
| 申请人 | Isis Innovation Limited;Imaxio SA | 发明人 | Spencer Alexandra Jane;Cottingham Matthew Guy;Hill Adrian Vivian Sinton;Hill Fergal |
| 分类号 | A61K39/04;A61K39/02;A61K39/00;C07K14/435;C07K16/12;C12N15/62 | 主分类号 | A61K39/04 |
| 代理机构 | Banner & Witcoff, Ltd. | 代理人 | Banner & Witcoff, Ltd. |
| 主权项 | 1. A polynucleotide sequence encoding a fusion protein comprising first and second domains, wherein the first domain of the fusion protein comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO: 1, or a fragment of said amino acid sequence of SEQ ID NO: 1 comprising at least 20 consecutive amino acids thereof; and wherein the second domain of the fusion protein comprises a mycobacterial antigen or an antigenic fragment thereof. | ||
| 地址 | GB | ||