Process of synthesis asymmetric polyurethane based membranes with hemocompatibility characteristics and membranes obtained by said process

摘要

The present invention refers to polymeric membranes and its synthesis with combination of innovative characteristics at the level of the bi-soft segment polyurethane material and at the level of the structure as integral asymmetric membranes. The hemocompability properties—non-hemolytic, non-thrombogenic and no platelet adhesion—combined with the high fluxes of permeation of O2 and CO2 have been designed for the use of the membranes in medical equipments that involve contact with blood like extracorporeal blood oxygenators and can be further designed for hemodialysers and imunnisolation barriers.

主权项

1. A process for synthesizing an integral asymmetric polyurethane membrane comprising:
a) polymerizing a first pre-polymer and a second pre-polymer, dissolved in a mixture of a first solvent, a second solvent and a catalyst, thereby providing a solution of a polyurethane; b) casting the solution, thereby providing a cast solution; c) evaporating the cast solution for a time period between about 30 to 100 seconds, thereby initiating formation of a first polymer layer having a cross-section with a thickness ranging from about 0.1 to 1 μm; d) extracting the first solvent by exchange with a non-solvent, thereby providing an integral asymmetric polyurethane membrane comprising the first polymer layer and a second polymer layer having a cross-section thickness of around 100 μm; e) immersing the integral asymmetric polyurethane membrane in water or an aqueous solution, thereby removing residual catalyst and solvents; and f) drying the integral asymmetric polyurethane membrane wherein the second solvent evaporates before the first solvent.