Positron emission tomography imaging method

摘要

Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.

主权项

1. A method of diagnosing or monitoring in a patient a folate receptor expressing cancer, the method comprising the steps of:
a. administering to the patient an effective amount of a composition comprising a compound of the formulawherein V is a folate receptor binding moiety, or an analog or derivative thereof; L is an optional bivalent linker; n is an integer selected from 1 to about 100; and Ar is an aryl group that includes one or more independently selected substituents, Rf, wherein Rf comprises a radiophore or a precursor to a radiophore; and an optional carrier therefor;
b. allowing sufficient time for the compound to bind to the cancer; c. detecting the compound bound to the cancer with an extra-corporeal PET imaging device; and d. diagnosing or monitoring the cancer extra-corporally using positron emission tomography.