Method and Apparatus for Image Scoring and Analysis

摘要

Methods and apparatuses for analyzing digital pathology images are provided. The methods and and apparatuses may provide estimates of staining intensity and proportion score in regions of interest within an image. Digital pathology images may be scored according to these metrics. The methods and apparatuses disclosed herein utilize various predetermined thresholds, parameters, and models to increase efficiency and permit accurate estimation of characteristics of a stained tissue sample.

主权项

1. A method for analyzing a digital pathology image comprising:
selecting at least one analysis region in the digital pathology image; separating the at least one analysis region into a tissue region and a background region using a predetermined separation threshold; identifying a plurality of nuclear prospects within the tissue region, wherein identifying the plurality of nuclear prospects includes:
calculating a principal component projection of the tissue region,segmenting the tissue region of the digital pathology image into a plurality of image layers via a spectral hashing function, anddetermining the plurality of nuclear prospects from among the plurality of layers; selecting nuclei from among the identified nuclear prospects; and generating a diagnostic score of the at least one analysis region based on the selected nuclei.