DUAL-ACTION, UNNATURAL PROLINE-RICH PEPTIDES AS ANTIBIOTIC AGENTS AND METHODS THEREOF

摘要

The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided.

主权项

1. A compound having the structure: wherein R1 is an alkyl substituent, the alkyl substituent being straight, branched or cyclic, an aryl substituent, a dye, a fluorophore, a conjugating agent, an intracellular directing group or an antimicrobial agent; wherein R2 and R3 are each independently, a hydrophobic alkyl or aryl moiety; and wherein n is from about 3 to about 10.