| 发明名称 |
HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF |
| 摘要 |
Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein. |
| 申请公布号 |
US2015315266(A1) |
申请公布日期 |
2015.11.05 |
| 申请号 |
US201414557851 |
申请日期 |
2014.12.02 |
| 申请人 |
University of Massachusetts ;Center for Disease Control and Prevention |
发明人 |
Thomas, JR. William D.;Ambrosino Donna M.;Mandell Robert;Sloan Susan;Babcock Gregory J.;Rupprecht Charles |
| 分类号 |
C07K16/10;A61K39/42 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated monoclonal antibody that competes for binding to rabies virus G protein with an antibody comprising:
(a) a heavy chain variable region CDR3 sequence comprising SEQ ID NO:5; (b) a light chain variable region CDR3 sequence comprising SEQ ID NO:8; (c) a heavy chain variable region CDR2 sequence comprising SEQ ID NO:4; (d) a light chain variable region CDR2 sequence comprising SEQ ID NO:7; (e) a heavy chain variable region CDR1 sequence comprising SEQ ID NO:3; and (f) a light chain variable region CDR1 sequence comprising SEQ ID NO:6. |
| 地址 |
Boston MA US |
