主权项 |
1. A method for preparing particles for in vivo delivery of a drug comprising:
(a) providing a drug, the structure of which comprises one or more hydroxyl or thiol groups; (b) conducting ring-opening polymerization of one or more cyclic monomers, wherein the cyclic monomers are cyclic esters, cyclic carbonates, cyclic phosphate, cyclic silicone, cyclic peptides or amino acid derivatives, or cyclic phosphazane, or a combination thereof, in an anhydrous, water-miscible solvent in the presence of (i) the drug as a polymerization initiator, and (ii) a polymerization catalyst, to form a covalent drug-oligomer or drug-polymer conjugate; and (c) forming particles comprising the drug-oligomer or drug-polymer conjugate, wherein the particles are about 2 nanometers to about 400 micrometers in diameter. |