Composites of Hydroxyapatite and Calcium Carbonate and Related Methods of Preparation and use

摘要

Carbonated calcium phosphate compositions and methods of preparation, affording enhanced biophysical properties.

主权项

1. A method of preparing a two-phase hydroxyapatite composition, said method comprising:
providing a hydroxyapatite material comprising a carbonatable calcium component, said carbonatable calcium component providing said hydroxyapatite material a Ca/P ratio≧about 1.67; sintering said hydroxyapatite material; and treating said sintered hydroxyapatite material with a carbon dioxide source to convert at least a portion of said carbonatable calcium component to a discontinuous calcium carbonate phase within a hydroxyapatite phase.