Process for the synthesis of E1 activating enzyme inhibitors

摘要

The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted (1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2/3-d]pyrimidin-7 yl}cyclopentyl)methyl sulfamates, which are El activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with El activity.