发明名称 |
METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS |
摘要 |
Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render CSCs amenable to treatment with conventional cancer therapies. In some embodiments, methods are provided that involve assaying PKA pathway activity to identify compounds that selectively target CSCs. |
申请公布号 |
WO2015168255(A1) |
申请公布日期 |
2015.11.05 |
申请号 |
WO2015US28239 |
申请日期 |
2015.04.29 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
PATTABIRAMAN, DIWAKAR;BIERIE, BRIAN;TAM, WAI, LEONG;WEINBERG, ROBERT, A. |
分类号 |
G01N33/50;C12Q1/68;G01N33/574 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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