发明名称 |
VACCINE FOR HPV INFECTION AND/OR HEPATITIS B CONTAINING HPV/HBS CHIMERIC PROTEIN AS ACTIVE INGREDIENT |
摘要 |
A chimeric protein of HPV-L2 peptide and HBs protein wherein the HPV-L2 peptide is (1) a peptide consisting of the core sequence region of 20 amino acid residues, (2) a peptide inside the core sequence region comprising 6 amino acid residues Gly-Gly-Leu-Gly-Ile-Gly or (3) a peptide consisting of 70 or less amino acid residues obtained by adding an amino acid sequence derived from HPV L2 protein at the N-terminal and/or the C-terminal of the core sequence region; and a vaccine for HPV infection and/or hepatitis B comprising the chimeric protein as an active ingredient. A vaccine comprising the chimeric protein of the present invention is the one that has an increased expression level in a host, an enhanced immune ability (early antibody induction) and a broader spectrum effective for a number of HPV types. |
申请公布号 |
EP2940133(A1) |
申请公布日期 |
2015.11.04 |
申请号 |
EP20130868570 |
申请日期 |
2013.11.28 |
申请人 |
THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE;JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF AGENCY OF NATIONAL INSTITUTE OF INFECTIOUS DESEASES |
发明人 |
YONEMURA, HIROSHI;SAKAGUCHI, MASASHI;IMAMURA, TAKASHI;MORI, SEIICHIRO;KANDA, TADAHITO |
分类号 |
C12N15/09;A61K39/00;A61K39/12;A61K39/29;A61K48/00;A61P31/20;A61P35/00;C07K14/02;C07K14/025;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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