| 摘要 |
<p>A novel technique for improving sulfur-containing amino acid-producing ability of a bacterium is developed, and thereby a sulfur-containing amino acid-producing bacterium, and a method for producing a compound such as a sulfur-containing amino acid are provided. A sulfur-containing amino acid, a related substance thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has a sulfur-containing amino acid-producing ability and has been modified so that the activity of the protein encoded by the yeeE gene, for example, the protein of the following (A) or (B), is increased in a medium, and collecting a sulfur-containing amino acid, a related substance thereof, or a mixture thereof from the medium:
(A) a protein consisting of the amino acid sequence of SEQ ID NO: 14,
(B) a protein consisting of the amino acid sequence of SEQ ID NO: 14, but which includes one or several amino acid substitutions, deletions, insertions, or additions, and wherein the increase in the intracellular activity of the protein improves the sulfur-containing amino acid-producing ability.</p> |
