MEGASTOKES AMINO-TRIAZOLYL-BODIPY COMPOUNDS AND APPLICATIONS TO LIVE NEURON STAINING AND HUMAN SERUM ALBUMIN FA1 DRUG SITE PROBING
摘要
A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
申请公布号
EP2938619(A1)
申请公布日期
2015.11.04
申请号
EP20130866739
申请日期
2013.12.26
申请人
NATIONAL UNIVERSITY OF SINGAPORE;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人
CHANG, YOUNG-TAE;ER, JUN CHENG;LEONG, CHERYL KIT MUN;YUN, SEONG WOOK;VENDRELL ESCOBAR, MARC;TANG, MUI KEE