Reverse micelle compositions for delivery of metal cations comprising a diglyceride and a phytosterol and method of preparation

摘要

The present invention relates to a method for the preparation of reverse micelles based on sterols, acylglycerols and metal salt and to reverse micelles obtained thereby. They are advantageously useful in the pharmaceutical and dietetic fields.

主权项

1. A method for preparing reverse micelles with an aqueous core of less than or equal to 100 nm, comprising:
(a) contacting (i) beta-sitosterol, (ii) an acylglycerol, (iii) water, (iv) ethanol, and (v) a water-soluble metal cation to form a mixture, and (b) stirring the mixture obtained in step (a), at 40° C. or less, and for a time sufficient to obtain formation of reverse micelles, said stirring being carried out mechanically at a speed from about 1000 to about 5000 r/min or by sonication,wherein water and acylglycerol are present in a ratio W=(water)/(acylglycerol) of less than or equal to about 2.5.