Diagnostic marker for effect of anticancer agent

摘要

The present invention enables to realize a convenient determination of a therapeutic effect of an anticancer agent on a cancer. Specifically, the present invention provides a diagnostic marker for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET; a diagnostic reagent for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET and the fragment of the extracellular domain of c-MET; and a method of testing an effect of an anticancer agent on a cancer, comprising (a) measuring a concentration of a fragment of an extracellular domain of c-MET in a biological sample from a subject, and (b) comparing the measured concentration of the fragment of the extracellular domain of c-MET with an indicator which presents a relationship between a concentration of the fragment of the extracellular domain of c-MET and the effect of the anticancer agent on the cancer.

主权项

1. A method for selecting and treating a subject having a lung cancer sensitive to a c-MET inhibitor comprising:
detecting a secreted fragment of a c-MET extracellular domain in a cell-free portion of a biological sample obtained from the subject having a lung cancer that is EGFR-inhibitor resistant using an antibody or an antigen-binding fragment thereof that binds to c-MET alpha chain of a c-MET extracellular domain, selecting a subject having a lung cancer sensitive to treatment with a c-MET inhibitor when said secreted fragment of the c-MET extracellular domain is detected, and treating the subject with a c-MET inhibitor selected from the group consisting of PHA-665752, SU11274, XL-880, XL-184, ARQ197, AMG208, AMG458, CD-355621, and MP470.