发明名称 Compounds useful against kinetoplastideae parasites
摘要 Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.
申请公布号 US9174960(B2) 申请公布日期 2015.11.03
申请号 US201013395571 申请日期 2010.09.20
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 发明人 Davioud-Charvet Elisabeth;Wenzel Ingrid Nicole;Müller Thomas J. J.;Hanquet Gilles;Lanfranchi Don Antoine;Leroux Frédéric;Gendron Thibault
分类号 C07D335/02;A61K31/382;C07C49/217;C07C49/235;C07C49/248;C07C49/255;C07C233/33;C07C255/56;C07D211/74;C07D213/50;C07D213/53;C07D311/14;C07D401/14;C07D409/04;C07D409/14 主分类号 C07D335/02
代理机构 Young & Thompson 代理人 Young & Thompson
主权项 1. A method of treating infection caused by a kinetoplastidae parasite, comprising administering to a mammal in need thereof an effective amount of at least one compound according to formula (I) wherein A is with W representing S(O)p with p=0 to 2, B and D each independently of each other represent an aryl group or a heteroaryl group optionally substituted by one to 5 substituents selected from the group consisting of:hydrogen atom,halogen atoms,hydroxy group,linear (C1-C4)alkyl groups or branched (C3-C4)alkyl groups,(C1-C4) alkoxy groups,(C1-C4) thioalkoxy groups,trifluoromethyl group,trifluoromethoxy group,pentafluorosulfanyl group,acetamide group,—OC(O)C6H5,formyl group,—COOH,—COOR with R representing a (C1-C4)alkyl group,—CH2OH,—CH2OR′ with R′representing a (C1-C4)alkyl group, —CH2OCH3 or a protecting group forming an acetal,—NH2,—NR2 with R representing a (C1-C4)alkyl group,—NO2,—CN, and and the pharmaceutically acceptable salts thereof.
地址 Paris FR