| 发明名称 |
Boronate ester compounds and pharmaceutical compositions thereof |
| 摘要 |
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases. |
| 申请公布号 |
US9175017(B2) |
申请公布日期 |
2015.11.03 |
| 申请号 |
US201414449275 |
申请日期 |
2014.08.01 |
| 申请人 |
|
发明人 |
Elliott Eric L.;Ferdous Abu J.;Kaufman Michael J.;Komar Sonja A.;Mazaik Debra L.;McCubbin Quentin J.;Nguyen Phuong M.;Palaniappan Vaithianathan;Skwierczynski Raymond D.;Truong Nobel T.;Varga Csanad M.;Zawaneh Peter N. |
| 分类号 |
A61K38/00;C07F5/04;C07F5/02;C07K5/078;C07K5/06;C07C233/83;A61K31/198;A61K31/454;A61K31/69 |
主分类号 |
A61K38/00 |
| 代理机构 |
Honigman Miller Schwartz and Cohn LLP |
代理人 |
Honigman Miller Schwartz and Cohn LLP ;Yang Lucy X.;O'Brien Jonathan P. |
| 主权项 |
1. A method for treating cancer, the method comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (II): or a pharmaceutically acceptable salt thereof, wherein: A is 0; P is Rc—C(O)—; Rc is RD; RD is 2,5-dichlorophenyl; Ra is isobutyl; Ra1 is hydrogen; each Rb1 and Rb2 independently is hydrogen; each Rb3 and Rb4 independently is —(CH2)p—CO2H; wherein one of carboxylic acids optionally forms a further bond with the boron atom; p is 0 or 1; n is 0 or 1; and the cancer is multiple myeloma, recurrence of multiple myeloma, lymphoma, or recurrence of lymphoma. |
| 地址 |
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