以螺－吲哚酮化合物之局部制剂治疗与关节之骨关节炎相关的疼痛之方法;METHODS OF TREATING PAIN ASSOCIATED WITH OSTEOARTHRITIS OF A JOINT WITH A TOPICAL FORMULATION OF A SPIRO-OXINDOLE COMPOUND

摘要

本文揭示用包含下式之螺-吲哚酮化合物之医药组合物治疗哺乳动物之与关节之骨关节炎相关的疼痛之方法，;该等方法提供该螺-吲哚酮化合物至受影响关节之滑膜中之极佳渗透，以在极小或可忽略不计之全身性暴露下有效降低该疼痛之严重度及/或缓和该疼痛。;are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure.