发明名称 |
REPROGRAMMING OF HUMAN WHARTONS JELLY CELLS TO PRODUCE HAIR CELLS |
摘要 |
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. The method can include; administering a nucleic acid that encodes HATH1 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the hWJCs; administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the WJCs by administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5; nucleic acids are administered includes a sequence of SEQ ID NO: 2, SEQ ID NO: 3, and/or SEQ ID NO: 4. |
申请公布号 |
US2015307837(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
US201514698157 |
申请日期 |
2015.04.28 |
申请人 |
Mellott Adam J.;Detamore Michael;Staecker Hinrich |
发明人 |
Mellott Adam J.;Detamore Michael;Staecker Hinrich |
分类号 |
C12N5/0793;C12N15/113;A61K35/30;C07K14/47 |
主分类号 |
C12N5/0793 |
代理机构 |
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代理人 |
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主权项 |
1. A method of transforming human cells into mechanosensory hair cells (MHCs), the method comprising:
causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. |
地址 |
Lawrence KS US |