发明名称 |
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND |
摘要 |
Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula;;wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof. |
申请公布号 |
US2015307497(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
US201314443598 |
申请日期 |
2013.11.18 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
SUGIMOTO Takahiro;NAKAMURA Minoru;SAKAMOTO Hiroki;SUZUKI Shinkichi;YAMADA Masami;KAMATA Makoto;KOJIMA Takuto;FUJIMORI Ikuo;SHIMOKAWA Kenichiro |
分类号 |
C07D487/04;C07D405/14 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
1. A compound represented by the formulawherein
ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each independently a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally having substituent(s), a C2-6 alkenyl group optionally having substituent(s), a C1-6 alkoxy group optionally having substituent(s), a C3-6 cycloalkyl group optionally having substituent(s), a C3-6 cycloalkoxy group optionally having substituent(s) or a C6-14 aryl group optionally having substituent(s), or a salt thereof. |
地址 |
Osaka-shi, Osaka JP |