Vinylsulfone-based 18f-labeling compositions and methods and uses thereof
摘要
A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group, wherein said labeling agent is capable of covalently bonding to thiol containing biomolecules such as proteins or peptides. Use of said labeling agents for labeling neurotensin and its variants are also disclosed.
申请公布号
AU2014225381(A1)
申请公布日期
2015.10.29
申请号
AU20140225381
申请日期
2014.03.08
申请人
UNIVERSITY OF SOUTHERN CALIFORNIA USC STEVENS
发明人
LI, ZIBO;CONTI, PETER S.;LI, LIN;WU, ZHANHONG;LIU, SHUANLONG;SHIVELY, JOHN E.;HORNE, DAVID