| 主权项 |
1. A complex comprising
an FGF-10 portion comprising a domain of a full length, unprocessed, naturally occurring fibroblast growth factor receptor 10 (FGF-10) polypeptide having a net positive charge, surface positive charge, a molecular weight of at least 4 kDa, and a charge per molecular weight ratio greater than that of a corresponding full length, unprocessed, naturally occurring FGF-10 polypeptide, which domain is a variant having one, two, three, four, or five amino acid substitutions, deletions, or additions relative to the corresponding domain of the naturally occurring FGF-10 polypeptide and that retains cell penetrating activity and a cargo portion comprising a heterologous protein or peptide or a small organic molecule; wherein the complex does not include a full length, unprocessed, naturally occurring FGF-10 polypeptide. |
