Compositions and Methods for Inducing Liver Regeneration by Administering Hepatocyte-Derived Exosomes

摘要

A pharmaceutical composition containing (1) a therapeutically effective amount of hepatocyte-derived exosomes; and (2) a pharmaceutically-acceptable carrier is provided. Also provided herein is a method of inducing liver regeneration in a patient in need thereof, the method including administering to the patient a therapeutic amount of hepatocyte-derived exosomes, wherein liver regeneration is induced. Methods for up-regulating synthesis of synthesis of sphingosine-1-phosphate (S1P) in a hepatocyte by contacting the hepatocyte with at least one vesicle containing sphingosine kinase 2, and, optionally, ceramide and neutral ceramidase, are also disclosed.

主权项

1. A pharmaceutical composition comprising:
a therapeutically effective amount of hepatocyte-derived exosomes; and a pharmaceutically-acceptable carrier.