| 发明名称 |
COMPOSITIONS OF ALDH1A1 INHIBITORS AND METHODS OF USE IN TREATING CANCER |
| 摘要 |
The present invention provides inhibitors of ALDH1A1 activity which have substantially no effect on either ALDH2 or ALDH3A1. Compositions and methods of use, as well as methods to treat cancer using the ALDH1A1 inhibitors, are also provided. |
| 申请公布号 |
US2015306108(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201514610106 |
申请日期 |
2015.01.30 |
| 申请人 |
Indiana University Research & Technology Corporation |
发明人 |
Hurley Thomas D.;Matei Daniela |
| 分类号 |
A61K31/522;A61K31/277;A61K31/4184;A61K31/519 |
主分类号 |
A61K31/522 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising
(a) a therapeutically effective amount of an inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1) selected from the group consisting ofCM001 1.1 μMCM045 2.5 μMCM009 5.3 μMCM047 0.31 μMCM010 1.3 μMCM053 0.21 μMCM020 0.45 μMCM055 0.24 μMCM025 2.1 μMCM056 5.4 μMCM026 0.80 μMCM057 0.92 μMCM028 2.0 μMCM302 1.1 μMCM037 4.6 μMCM306 3.5 μMCM038 0.26 μMCM307 0.57 μMCM039 0.41 μMCM037a 23 μMCM037g 3.3 μM. or its pharmaceutically acceptable salt or a solvate thereof, and (b) a pharmaceutically suitable carrier. |
| 地址 |
Indianapolis IN US |
