摘要 |
The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. |
申请人 |
ABBVIE INC. |
发明人 |
RAMASUBRAMANYAN, NATARAJAN;YANG, LIHUA;HERIGSTAD, MATTHEW, OMON;YANG, HONG;SUBRAMANIAN, KARTIK;ZENG, XIAOBEI;DONG, DIANE, D.;LIM, WEN, CHUNG;GIFFORD, KATHREEN, A.;KAYMAKCALAN, ZEHRA;CHUMSAE, CHRISTOPHER |