发明名称 |
Human CD3-specific antibody with immunosuppressive properties |
摘要 |
<p>Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections. <IMAGE></p> |
申请公布号 |
EP1400534(B1) |
申请公布日期 |
2015.10.28 |
申请号 |
EP20020020236 |
申请日期 |
2002.09.10 |
申请人 |
AFFIMED GMBH |
发明人 |
LE GALL, FABRICE;KIPRIYANOV, M.SERGEY;LITTLE, MELVYN;REUSCH, UWE |
分类号 |
C07K16/28;A61K39/395;A61K48/00;A61P37/06;C12N5/10;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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