<p>The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.</p>
申请公布号
EP2468767(B1)
申请公布日期
2015.10.28
申请号
EP20120152612
申请日期
2007.06.22
申请人
WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人
GARRETT, THOMAS P.J.;ADAMS, TIMOTHY EDWARD;LOVRECZ, GEORGE;MCKERN, NEIL MORETON;LAWRENCE, MICHAEL COLIN;SPARROW, LINDSAY GALE;WARD, COLIN WESLEY;LOU, MEIZHEN;STRELSTOV, VICTOR