Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof

摘要

The invention relates to compounds corresponding to formula (I);
in which R1, R2 and R3 are as defined in Claim 1, and also to the process for preparing them and to their therapeutic use.

主权项

1. A compound corresponding to formula (I):in which:
R1 represents:
—(C1-C4)alkyl—(C1-C4) haloalkyl R 2represents:
a group: a group: a group: -A -X R3 represents:
—Hhalogen—(C1-C6)alkyla cyano group—CO2H—CONH2 A represents:
an aryl or heteroaryl group X is absent or represents:
halogena cyano groupan oxo group—(CH2)nOH—(C1-C6)haloalkyl—(C1-C6)alkyl—(C1-C6)alkoxy—(CH2)n-aryl—CHOH-arylheterocycleheteroaryl—(C1-C6)alkyl-heterocycle—(C1-C6)alkyl-heteroaryl—(C1-C6)alkyl-COORa—(C1-C6)alkyl-NRaRb-heteroaryl-(CH2)n-NRaRb—(CH2)n-NRa—C(O)—Rb—NRaRb—NRa—(CH2)n-O—Rb—NRa-heterocycle—NRa-aryl—NRa—C(O)—(CH2)n-NRaRb—NRa—C(O)-aryl—NRaC(O)—(C1-C6)alkyl—NRa—C(O)—(C1-C6)alkyl-aryl—NRa—C(O)—(CH2)n-O—Rb—NRa—SO2-(CH2)n-aryl—NRa—SO2-(CH2)n-NRaRb—NRa—SO2-Rb—NRa—SO2-aryl-O-aryl—NRa—SO2-aryl-(CH2)n-NRb—C(O)—Rb—COORa—CONRaRb—C(O)—NRa—(CH2)n-O—Rb—C(O)—NRa-aryl-C(O)—NRaRb—C(O)—NRa—(CH2)n-NRaRb—C(O)—NRa—(CH2)n-heteroaryl—O—(CH2)n-NRaRb—O-heterocycle—CO-heterocycle—CO-heteroaryl—SO2NRaRb—SO2-heterocycle Ra and Rb represent, independently:
—H—(C1-C6)alkyl
n represents 0, 1, 2 or 3in the form of the base or of an acid-addition salt, and also in hydrate form.