| 发明名称 | Combination therapy for MDS | ||
| 摘要 | Disclosed are compositions and methods for the treatment of disorders such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The disclosed methods include administering to an individual in need of such treatment a composition that may include an IRAK1/4 inhibitor. In other aspects, the method may include administration of a BLC2 inhibitor. | ||
| 申请公布号 | US9168257(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US201414284521 | 申请日期 | 2014.05.22 |
| 申请人 | Children's Hospital Medical Center | 发明人 | Starczynowski Daniel;Rhyasen Garrett W. |
| 分类号 | C07H21/02;C07H21/04;A61K48/00;A61K31/5377;C12N15/113;A61K31/4184;A61K31/495 | 主分类号 | C07H21/02 |
| 代理机构 | Frost Brown Todd LLC | 代理人 | Frost Brown Todd LLC |
| 主权项 | 1. A method of treating myelodysplastic syndrome (MDS) in an individual having an MDS characterized by increased IRAK1 activation, comprising the step of administering to said individual a composition comprising an IRAK1/4 inhibitor. | ||
| 地址 | Cincinnati OH US | ||