| 发明名称 | Antibodies against human CSF-1R | ||
| 摘要 | The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. | ||
| 申请公布号 | US9169323(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US201113582964 | 申请日期 | 2011.03.03 |
| 申请人 | HOFFMANN-LA ROCHE INC. | 发明人 | Fertig Georg;Fidler Alexander;Kaluza Klaus;Thomas Marlene;Ries Carola;Seeber Stefan |
| 分类号 | A61K39/395;A61K51/10;A61K39/00;C07K16/00;C12P21/08;A61P35/00;A61P35/04;C07K16/28 | 主分类号 | A61K39/395 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An antibody that binds to human CSF-1R, characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO: 1, a CDR2 region of SEQ ID NO: 2, and a CDR1 region of SEQ ID NO:3, and the light chain variable domain comprises a CDR3 region of SEQ ID NO 4, a CDR2 region of SEQ ID NO:5, and a CDR1 region of SEQ ID NO:6, or a CDR grafted, humanized, or T cell epitope depleted antibody variant thereof. | ||
| 地址 | Nutley NJ US | ||