发明名称 |
BEHANDLING AF STRUKTURERET PEPTID |
摘要 |
The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage. |
申请公布号 |
DK2393520(T3) |
申请公布日期 |
2015.10.26 |
申请号 |
DK20100704902T |
申请日期 |
2010.02.04 |
申请人 |
BICYCLE THERAPEUTICS LIMITED |
发明人 |
BERNARD, ELISE;LOAKES, DAVID;VAYSBURD, MARINA;HEINIS, CHRISTIAN;WINTER, GREGORY PAUL |
分类号 |
A61K47/48;G01N33/68 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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