COMPOSITIONS AND METHODS FOR MODULATING INNATE AND ADAPTIVE IMMUNE SYSTEMS

摘要

Compositions and methods for modulating the innate and adaptive immune systems in a subject. The compositions and methods may inhibit the function of inhibitory receptors and enhance activity of activating receptors. The method typically includes the steps of: administering to the subject a composition having a therapeutic peptide or multivalent polypeptide having multiple copies of the therapeutic peptide in an amount sufficient to increase activity of the immune system in the subject. Compositions may include a carrier; at least one agent selected from the group consisting of: an anti-inflammatory agent, a cytotoxic T cell proliferation agent, and/or a NK cell proliferation agent; and a selected therapeutic peptide or multivalent polypeptide. The compositions may also include an immunoglobulin admixed therewith to enhance passive immunoprotection.

主权项

1. A method of stimulating the immune system of an immunocompromised subject, the method comprising: administering to the immunocompromised subject a composition comprising a therapeutic peptide or a multivalent structured polypeptide comprising multiple copies of the therapeutic peptide, the therapeutic peptide consisting of 5 to 8 amino acids and selected from the group consisting of:(SEQ ID NO: 1)VGGGSandX1-P-S-X2-X3-X4-X5-X6,wherein
X1 is selected from the group consisting of H and N, or is absent; X2 is selected from the group consisting of L, S, N, and H; X3 is selected from the group consisting of N, K, G, L, P, and A; X4 is selected from the group consisting of A, S, and L, or is absent; X5 is selected from the group consisting of S and L, or is absent; and X6 is G, or is absent;wherein the therapeutic peptide or multivalent structured polypeptide is in an amount sufficient to activate and/or stimulate proliferation of immune cells in the subject.