Materials and Methods for Preventing and Treating Anastomotic Leaks

摘要

Materials and methods for preventing and treating anastomotic leaks are disclosed. Data establishes that pathogenic microbes interfere with establishing epithelial cell barriers in anastomoses and, more generally, with the reconnection of any two portions of like or different tissues comprising epithelia. Suitable prophylactic and therapeutic composition comprise, e.g., a phosphorylated high molecular weight polyethylene glycol compound.

主权项

1. A method of treating anastomotic leakage comprising administering a therapeutically effective amount of a composition comprising a compound selected from the group consisting of high molecular weight polyethylene glycol and inorganic phosphorus.