METHOD FOR DIAGNOSING AND TREATING KIDNEY INJURY OR DISEASE

摘要

The protein kinase C and casein kinase 2 substrate in neurons (Pacsin) is a subfamily of membrane-binding proteins, participates in vesicle trafficking and cytoskeleton organization. Pacsin 2 expression is significantly upregulated during the repair phase of post ischemia-reperfusion injured (IRI) kidneys, especially on the apical brush border of proximal tubules, which experienced massive damage. Described herein are methods, kits and systems for the diagnosis, selection and treatment of kidney injury and kidney diseases.

主权项

1. A method of diagnosing kidney injury or a kidney disease, comprising:
assaying a biological sample obtained from a subject to determine a Pacsin 2 expression level, wherein determining the Pacsin 2 expression level is by application of a reagent that reacts with Pacsin 2 or a complex comprising Pacsin 2, and wherein the reagent comprises a detectably labeled probe; comparing the Pacsin 2 expression level to a reference level; and diagnosing the kidney injury or a kidney disease if the Pacsin 2 expression level is higher than the reference level.